In these days of distress a new ray of hope emerged with recent research which confirmed that by taking curd in diet, we may bring down fatality rate in COVID-19.
Explained: How Curd May Reduce COVID-19 Deaths in India
New Delhi (ABC Live India): India is facing
one of the deadly attacks of COVID-19 pandemic now a day, the numbers of deaths
is increasing day by day in these days of distress a new ray of hope emerged with
recent research which confirmed that by taking curd in diet, we may bring down fatality
rate in COVID-19.
It is beyond today scientific understanding that why Coronavirus causes mild symptoms in most of people, but proves fatal for
others. The Health investigations of COVID-19 patients confirmed that the majority of the COVID-19
deaths were caused by a disturbed immune response to the infection in the lungs of
the patients, rather by the virus itself.
The health reports of COVID-19 patients who
lost their lives also confirmed that their blood was crowded with high levels
of immune system proteins called cytokines. (Cytokine Storm).
What is Cytokine Storm
is process where human immune system starts to attack its own cells and tissues
instead of the virus (Coronavirus), the meaning thereby that the cell communication
of human Immune system does not work during Cytokine Storm.
How Curd can mitigate Cytokine Storms in COVID-19
Curd is a fermented probiotic dairy drink. Molecules in this fermented probiotic drink proved to ease cytokine storm which is the major cause of Covid-19 death. In India Curd is an integral part of tradition Indian diet and has lost its relevance in urban India, facing the worst attack of COVID-19.
A recent study from Ben-Gurion University of the Negev (BGU)
found that isolated molecules from probiotic-rich dairy products(Curd) could have potential as novel drug
candidates for fighting against pathogenic bacteria and treating inflammatory diseases,
including the cytokine storm related to Coronavirus disease 2019 (COVID-19).
Findings from the study were published in
the peer-reviewed publication Microbiome. Probiotics
are considered beneficial bacteria found in fermented foods like kefir and
yogurt. Previous research suggests that probiotics may also support the immune
system, improve the diversity and balance of microbial populations in the gut
and possibly protect humans from harmful bacterial infections.
A study from
Monash University in Melbourne identified two molecules in the gut microbiome,
which houses probiotic bacteria that may play a role in treating severe
COVID-19 and asthma attacks.
In this recent study, researchers from BGU
isolated molecules from predominant yeast in probiotic-rich kefir. These
molecules significantly reduced virulence of the bacteria that causes cholera.
According to the investigators, the
anti-bacterial effect of the kefir-secreted molecules centered on their ability
to disrupt bacterial cell communication and interfered in assembly of bacterial
aggregates. They added that the achievement of blocking cell communication with
these molecules among bacterial cells represents a promising and potentially
effective approach to combating antibiotic-resistant bacteria.
A follow-up study found that the isolated
molecules also exhibited anti-inflammatory properties when tested in several
different pathological conditions and diseases. In one case, the molecules
accelerated the healing of mice that were undergoing a “cytokine storm,” a
potentially lethal immune response involved in COVID-19 and another conditions.
The molecules isolated from the probiotic yogurt eliminated the cytokine storm
and also improved immune system function. The investigators believe that these
isolated molecules could thus be used as novel drug candidates for inflammatory
Professor Raz Jelinek, a corresponding study
author, said in a statement that
the findings from this study are notable, given that they are the first to
demonstrate that molecules secreted in probiotic dairy products can reduce
human pathogenic bacteria virulence.
"In fact, our research illuminates for
the first time a mechanism by which milk fermented probiotics can protect
against pathogenic infections and aid the immune system,” Jelinek said.
“Following promising results in animal models, we look forward to administering
these drug candidates to humans, for example to patients who are experiencing a
cytokine storm due to COVID-19 infection, or people suffering from acute
inflammatory bowel pathologies, such as Crohn's disease."
"In a reality where antibiotic-resistant
bacteria are becoming an imminent threat, the novel molecules discovered by BGU
scientists pave a completely new path for fighting bacterial infections by
disrupting cell-cell communications in pathogenic bacteria,” added Josh Peleg,
chief executive officer of BGN Technologies. “Moreover, the dramatic
anti-inflammatory activities of the molecules may open new avenues for
therapeutics and scientifically proven probiotic food products."